The break in treatment allows your blood cell counts to recover, as ifosfamide can cause bone marrow suppression when the bone marrow does not make adequate amounts of blood cells. Find patient medical information for ifosfamidemesna intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Grapefruit may interact with ifosfamide and lead to unwanted side effects. Ifex ifosfamide for injection singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. Ifosfamide is listed in the worlds largest and most authoritative dictionary database of abbreviations and acronyms. Under object type, select adobe acrobat document and click ok. In adult patients with inoperable locally advanced or metastatic softtissue sarcoma, do combination chemotherapy regimens containing ifosfamide have an advantage in terms of response rate, time to progression, or survival, as compared with similar regimens without ifosfamide when used as firstline therapy. Store intact vials at room temp or under refrigeration. Supportive therapy should be maintained until their complete resolution. Ifosfamide jordan university of science and technology. Neurotoxicity related to the use of ifosfamide is a wellknown complication. You can help protect yourself from scammers by verifying that the contact is a microsoft agent or microsoft employee and that the phone number is an official microsoft global customer service number.
Also, avoid persons who have taken oral polio vaccine within the. Further dilution in 50 ml d 5 w, ns, or lactated ringers to a final concentration of 0. Ifosfamide ifex oncology intravenous dilution data. It is not known if mesnex passes into your breast milk. Ifosfamide exhibits dosedependent pharmacokinetics in humans. Medlineplus information on ifosfamide a lay language summary of important information about this drug that may include the following. Ifosfamide is approved to be used with other drugs to treat. How can i embed any file type into microsoft word using. Since the growth of normal body cells may also be affected by ifosfamide, other effects will also occur.
Adjust dose accordingly if ifosfamide dose changes. A healthcare provider will give you this injection. Jul 30, 2018 ifosfamide for injection ifosfamide for injection, usp singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. Ifosfamide belongs to the group of medicines called alkylating agents. Dailymed ifosfamide injection, powder, for solution. Pdf successful treatment of ifosfamide neurotoxicity. Dosage and duration of treatment andor treatment intervals depend on the. Because of the potential for serious adverse events and the tumorigenicity shown for ifosfamide in animal studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Used as an antineoplastic agent in treatment of leukemia, lymphoma, and cancers of the lung, ovary, testes, and other organs. Click convert to make the pdf in word format on windows.
Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. Pdr drug summaries are concise pointofcare prescribing, dosing and administering information to help phsyicans more efficiently and accurately prescribe in their practice pdr s drug summaries are available free of charge and serve as a great resource for us based mds, dos, nps and pas in patient practice. Ifosfamide has been shown to be carcinogenic in rats, with female rats showing a significant. Ifosfamide side effects, dosage, interactions drugs.
Ifex ifosfamide for injection, usp singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. Ifosfamide is also being studied in the treatment of other types of cancer. Animal studies indicate that the drug is capable of causing gene mutations and. Ifosfamide intravenous route precautions mayo clinic. Ifex is an alkylating drug indicated for use in combination with certain other. Ifosfamide is give through an infusion into a vein intravenous, iv. Please click here for important safety information, including boxed warning regarding hepatic impairment, and click here 2 for full prescribing information. Injections are prepared for parenteral use by adding sterile water for injection, usp, or.
Mesnex injection is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage weight by weight ww at the time of ifosfamide administration and 4 and 8 hours after each dose of ifosfamide. Embedding foreign objects pdf, txt, gif, etc into microsoft word using openxml 2. Sections or subsections omitted from the full prescribing information are. The molecular formula is c 7 h 15 cl 2 n 2 o 2 p and its molecular weight is 261. Purpose the efficacy of paclitaxel was evaluated in combination with ifosfamide and cisplatin as secondline chemotherapy for patients with relapsed.
Run and import pdf files into the program by clicking add pdf. Ifosfamide is an anticancer antineoplastic or cytotoxic chemotherapy drug. Mesnex may be given on a fractionated dosing schedule of three bolus intravenous injections as outlined below. Save money on your ifosfamide injection prescription by switching to tevas fdaapproved generic version. Always consult your healthcare provider if you have questions or concerns. Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions.
Ifosfamide is 32chloroethyl22chloroethylaminotetrahydro2h1,3,2oxazaphosphorine 2oxide. It is not available orally, so is given iv over 124 hours. Combination of paclitaxel, ifosfamide, and cisplatin is an effective. In all of these studies ifosfamide was administered as an i.
Ifosfamide is passed into the breast milk and may cause neutropenia, thrombocytopenia, low haemoglobin concentrations and diarrhea in children. Ifosfamide solution for injection drug information, side. In general, dose selection for an elderly patient should be. Ifosfamide can cause severe neurotoxicity resulting in encephalopathy and death. Carcinogenesis, mutagenesis, impairment of fertility ifosfamide has been shown to be carcinogenic in rats, with female rats showing a. When you click on object, youll get a dialog box, and here you will want to click on the create from file tab. Germ cell tumors with somatic transformation into pnet have in certain cases been successfully treated with chemotherapy that includes cycles of. Ifosfamidebased combination chemotherapy in advanced soft. Go to the output file format as following, choose doc. Estimation of costbased prices for injectable medicines in the who. The file location will now appear on the object dialog box. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
Open the word document and select insert on the ribbon. Reconstitution reconstitute powder with swfi or bacteriostatic swfi 1 g in 20 ml or 3 g in 60 ml to a concentration of 50 mgml. Click on the object button, and a dialog box will open. Please click here for important safety information, including boxed warning regarding hepatic impairment, and click here 3 for full prescribing information. Following activation in the liver, ifosfamide interferes with dna through formation of phosphotriesters and dnadna crosslinks, thereby inhibiting protein synthesis and dna synthesis. In two of the former studies with ice combination, drug doses were lower and studies. Purpose ifosfamide is approved by the food and drug administration 1 fda 2 to treat germ cell testicular cancer. While the use of methylene blue is a known antidote, symptomatic treatment of the central nervous system cns effects. Voorma, ingevolge het besluit van het college voor promoties.
Ifosfamide, carboplatin, and etoposide ice reinduction. Guidelines for the administration of mesna with ifosfamide. Clinical pharmacology of ifosfamide and metabolites. Information for the patient ifosfamide injection 1 g and 2 g ifosfamide read all of this leaflet carefully before you are given this medicine because it contains important information for you. In some cases, health care professionals may use the trade name ifex when referring to the generic drug name ifosfamide. Definition from the nci drug dictionary detailed scientific definition and other names for this drug. Ifosfamide is listed in the worlds largest and most authoritative dictionary database of abbreviations and acronyms the free dictionary. See actual entry in rtecs for complete information. Oct 24, 2016 if ifosfamide is used during pregnancy, or if the patient becomes pregnant while taking this drug or after treatment, the patient should be apprised of the potential hazard to a fetus. Only select registry of toxic effects of chemical substances rtecs data is presented here.
Ifosfamide is an alkylator agent, meaning it has a molecular structure that binds to dna and creates a crosslink that blocks replication of the dna. Ifosfamide injection 1g summary of product characteristics. Ifosfamide may lower your bodys resistance and there is a chance you might get the infection the immunization is meant to prevent. Ifosfamide is a parenterally administered alkylating agent similar to cyclophosphamide that is used in the treatment of several forms of cancer including lymphomas, sarcoma and advanced forms of solid organ cancer such as breast, testicular, ovarian, gastric and lung cancer. Ifosfamide medical definition merriamwebster medical. Ifosfamide investigated as a drug, mutagen, reproductive effector, and tumorigen. Several payment sources exist for cancer drugs in ontario, depending on the drug, disease indication, and how and where it is. Open the word file, the file originally saved in pdf is inserted into the word document successfully. Place your cursor by clicking on the area where you wish to insert the pdf document. It is used in patients who have already been treated with two other types of chemotherapy ifosfamide is also being studied in the treatment of other types of cancer.
Reactions may include hypotension, dyspnea, upper airway edema, lip swelling, rash, pruritus, and urticaria. Aug, 2018 ifex ifosfamide for injection, usp singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. Ifosfamide is 32chloroethyl22chloroethylaminotetrahydro2h. Ifosfamide for injection ifosfamide for injection, usp singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. Phase iii trial of ifosfamide with or without paclitaxel in advanced. Data sources include ibm watson micromedex updated 10 apr 2020, cerner multum updated 6 apr 2020. Pdf successful treatment of ifosfamide neurotoxicity with. No dosage adjustment provided in the manufacturers labeling. Ixempra ixabepilone dosing and administration guide. Clear solution mixed into larger bags of fluids drug monograph. Ifosfamide neurotoxicity may become manifest within a few hours to a few days after first administration and in most cases resolves within 48 to 72 hours of ifosfamide discontinuation. Drinking alcohol can increase certain side effects of ifosfamide, especially nausea and vomiting.
It is a nitrogen mustard alkylating agent used in the treatment of advanced breast cancer. Ifosfamide fda prescribing information, side effects and. Nov 09, 2018 ifosfamide is injected into a vein through an iv. The most common adverse reactions in chemotherapyinduced nausea and vomiting in.
If ifosfamide is used during pregnancy, or if the patient becomes pregnant while taking this drug or after treatment, the patient should be apprised of the potential hazard to a fetus. Multiple dosage levels of one formulation of one medicine eg, ifosfamide powder for injection in 1 g and 2 g forms are counted as one instance. Ifosfamide chemically interferes with the synthesis of the genetic material dna and rna of cancer cells by crosslinking of dna strands, which prevents these cells from being able to reproduce and continue the growth of the cancer. If this medicine accidentally gets on your skin, wash it thoroughly with soap and warm water. Dailymed ifex ifosfamide injection, powder, for solution. You may be able to overcome this with stronger flavored herbs such as basil, sage, or thyme. Ifex ifosfamide dosing, indications, interactions, adverse. Ifa is a racemic mixture of two enantiomeric forms, rifa and sifa with a stereoselective metabolism by cyp3a4 and cyp2b6, leading either to bioactive or to toxic pathways. Ifosfamide injection is used in combination with other medicines to treat cancer of the testicles ifosfamide interferes with the growth of cancer cells, which are eventually destroyed. Tech support scams are an industrywide issue where scammers trick you into paying for unnecessary technical support services. Risk factors for the development of cns toxicity include the following. This document plus the full product monograph, prepared for. In the text group click the dropdown arrow for object and select object. Carcinogenesis, mutagenesis, impairment of fertility.
Ifosfamide ifo, sold under the brand name ifex among others, is a chemotherapy medication used to treat a number of types of cancer. The usual recommended dosage of ifosfamide for treating testicular cancer is 1. This typically regresses after completing treatment. Ifosfamide is a synthetic structural isomer of cyclophosphamide that has been approved for concurrent use with other drugs usually cisplatin, etoposide, or vinblastine in the treatment of metastatic germcell testicular cancer and some especially pediatric sarcomas. Purpose to determine if paclitaxel added to ifosfamide as firstline. We report the case of a 19yearold woman, with relapsed hodgkins lymphoma, who developed ifosfamideinduced encephalopathy 16 days after the first exposure to rituximab, ifosfamide, carboplatin. The information on this website is intended for informational purposes only and is not a substitute for medical advice. Here are the steps to inserting a pdf file into a word document. Mesna equivalent of 40% total daily ifosfamide dose given as iv bolus postifosfamide mesna equivalent of 40% total daily ifosfamide dose given orally 2 and 6 hours after the end of the ifosfamide infusion. Ifex ifosfamide dose, indications, adverse effects.
We report the case of a 19yearold woman, with relapsed hodgkins lymphoma, who developed ifosfamide induced encephalopathy 16 days after the first exposure to rituximab, ifosfamide, carboplatin. Ifosfamide definition of ifosfamide by medical dictionary. In addition, other persons living in your house should not take oral polio vaccine since there is a chance they could pass the polio virus on to you. Ifosfamide definition ifosfamide is an anticancer antineoplastic agent. Do not breastfeed during treatment and for 1 week after the last dose of mesnex or ifosfamide. Embed pdf in word embed a pdf document into microsoft word.
The amount of ifosfamide that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated. Ifosfamide, like cyclophosphamide, is an oxazophosphorine alkylating agent. Looking for online definition of ifosfamide or what ifosfamide stands for. This can last for about 24 hours after taking ifosfamide.
Ifosfamide ifa is a potent alkylating antitumoral agent, but its use is limited by neurological side effects. The object dialog box will appear select create from file. Ifosfamide may only be taken as an injection into the vein. This includes testicular cancer, soft tissue sarcoma, osteosarcoma, bladder cancer, small cell lung cancer, cervical cancer, and ovarian cancer. Find patient medical information for ifosfamide intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Mesnex mesna dosing, indications, interactions, adverse.
Incidence and prevention of bladder toxicity from cyclophosphamide. Ifosfamide comes as powder to be mixed with liquid to be injected over at least 30 minutes intravenously into a vein by a doctor or nurse in a medical facility. Since dose fractionation of ifosfamide over several days increases its therapeutic index, we chose to maximize the dose fractioning by selecting a continuousinfusion schedule 1. For certain toxicities, an initial dose reduction of 20% should be made, followed by an additional. For outlook, click inside of the body of an item, such as an email message or calendar event. Additional 20% dose reduction if toxicities recur 25 mgm2 iv over 3 hours every 3 weeks.